Indole-2-carboxylic acid → HCID 178520946, 화합물

반응식

[NH:1]1[CH2:5][CH2:4][CH2:3][C@@H:2]1[CH2:6][OH:7].[F:8][C:9]([F:20])([F:19])[C@H:10]1[CH2:15][CH2:14][C@H:13]([C:16](O)=[O:17])[CH2:12][CH2:11]1.N1C2C(=CC=CC=2)C=C1C(O)=O>>[F:8][C:9]([F:19])([F:20])[C@H:10]1[CH2:11][CH2:12][C@H:13]([C:16]([N:1]2[CH2:5][CH2:4][CH2:3][C@@H:2]2[CH2:6][OH:7])=[O:17])[CH2:14][CH2:15]1

참가 물질

반응물 3

HCID 72899Indole-2-carboxylic acid

HCID 2724541Prolinol, (R)-

HCID 178525710HCID 178525710, 화합물

생성물 1

HCID 178520946HCID 178520946, 화합물

실험 절차

The title compound was prepared according to the procedure described in Step 1 of EXAMPLE 3 using (R)-pyrrolidin-2-ylmethanol and trans-4-(trifluoromethyl)cyclohexanecarboxylic acid instead of (R)-3-(pyrrolidin-2-ylmethoxy)picolinamide dihydrochloride and indole-2-carboxylic acid.

출처 및 근거

ORD 기록: ord-727d9fbb543f4216be0da13ae6ad5a94
출처 데이터셋: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08809380B2

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