Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
5-Cyclopropyl-1,2-oxazole-3-carboxylic acid → (R)-ethyl 3-((1-(5-cyclopropylisoxazole-3-carbonyl)pyrrolidin-2-yl)methoxy)picolinate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 5-Cyclopropyl-1,2-oxazole-3-carboxylic acid | HCID 1092113 | — |
| 반응물 | HCID 86762606 | HCID 86762606 | — |
| 반응물 | HCID 178493765 | HCID 178493765 | — |
| 생성물 | (R)-ethyl 3-((1-(5-cyclopropylisoxazole-3-carbonyl)pyrrolidin-2-yl)methoxy)picolinate | HCID 86666099 | — |
반응 단계
The title compound was prepared according to the procedure described in Step 5 of EXAMPLE 31 using (R)-ethyl 3-(pyrrolidin-2-ylmethoxy)picolinate bis(trifluoroacetic acid) salt (EXAMPLE 34 Step 1) and 5-cyclopropylisoxazole-3-carboxylic acid instead of ammonium chloride and 5-methoxy-3-(((R)-1-(trans-4-(trifluoromethyl)cyclohexanecarbonyl)pyrrolidin-2-yl)m ethoxy)picolinic acid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08809380B2 |
| 출처 데이터셋 | uspto-grants-2014_08 |
| ORD ID | ord-39f3c795ce094d46abf200638100145d |
| 출처 메모 | uspto-grants-2014_08 |