5-Cyclohex-1-enyl-6-(2,2,2-trifluoroethoxy)nicotinic acid methylester → Methyl 5-cyclohexyl-6-(2,2,2-trifluoroethoxy)nicotinate

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5-Cyclohex-1-enyl-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid methyl ester (163 mg, 517 μmol) was combined with ethanol (5 mL) to give a colorless solution. Palladium (10% on charcoal, 16.3 mg, 517 μmol) was added and the suspension was evacuated and flushed with hydrogen 3 times and stirred for 1.5 h at ambient temperature. Afterwards the reaction mixture was filtered through Celite and concentrated in vacuo to give the title compound (95 mg, 58%) as grey solid; MS (EI) 318.1 (M+H)+.

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