(S)-(-)-1-Amino-2-(methoxymethyl)pyrrolidine → (S)-5-cyclopentyl-N-(2-(methoxymethyl)pyrrolidin-1-yl)-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxamide

HRID 240707

반응식

HRID 240707 반응식
[CH:1]1([C:6]2[CH:7]=[C:8]([C:18]([OH:20])=O)[CH:9]=[N:10][C:11]=2[O:12][CH2:13][C:14]([F:17])([F:16])[F:15])[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:21][O:22][CH2:23][C@@H:24]1[CH2:28][CH2:27][CH2:26][N:25]1[NH2:29]>>[CH:1]1([C:6]2[CH:7]=[C:8]([C:18]([NH:29][N:25]3[CH2:26][CH2:27][CH2:28][C@H:24]3[CH2:23][O:22][CH3:21])=[O:20])[CH:9]=[N:10][C:11]=2[O:12][CH2:13][C:14]([F:15])([F:16])[F:17])[CH2:2][CH2:3][CH2:4][CH2:5]1

참가 물질

3

반응물 2

HCID 7156993(S)-(-)-1-Amino-2-(methoxymethyl)pyrrolidineHCID 712941865-Cyclopentyl-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxylic acid

생성물 1

HCID 71294153(S)-5-cyclopentyl-N-(2-(methoxymethyl)pyrrolidin-1-yl)-6-(2,2,2-trifluoroethoxy)-3-pyridinecarboxamide

실험 절차

The title compound was synthesized in analogy to Example 1 using 5-cyclopentyl-6-(2,2,2-trifluoro-ethoxy)-3-pyridinecarboxylic acid (example 14c) and (2S)-2-(methoxymethyl)-1-pyrrolidinamine (CAN 59983-39-0) as starting materials; MS (EI) 402.3 (M+H)+.

출처 및 근거

ORD 기록
ord-1dfedfafb04f446bb312dfa1068696f8
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08648099B2

연결된 노트

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