Selenium Dioxide → 2-(3,5-Difluorophenyl)-2-oxoacetaldehyde

반응식

[CH3:1][C:2]([C:4]1[CH:9]=[C:8]([F:10])[CH:7]=[C:6]([F:11])[CH:5]=1)=[O:3].[Se](=O)=[O:13]>>[F:11][C:6]1[CH:5]=[C:4]([C:2](=[O:3])[CH:1]=[O:13])[CH:9]=[C:8]([F:10])[CH:7]=1

참가 물질

반응물 2

HCID 24007Selenium Dioxide

HCID 5185963',5'-Difluoroacetophenone

생성물 1

HCID 187847012-(3,5-Difluorophenyl)-2-oxoacetaldehyde수율 85.6%

실험 절차

(3,5-Difluorophenyl)(oxo)acetaldehyde (28 g, 84%) was prepared from 3,5-difluoro acetophenone (30.0 g, 192.3 mmol) and selenium dioxide (23.55 g, 214.0 mmol) according to the typical procedure used for Preparation 1.

후처리

customused for Preparation 1

출처 및 근거

ORD 기록: ord-2cf9a89615424db0adb15b08cd3ec8e5
출처 데이터셋: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08809525B2

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