(3-Chlorophenyl)boronic acid → HCID 53354726, 화합물

반응식

Br[C:2]1[N:7]=[N:6][C:5]([NH2:8])=[N:4][C:3]=1[C:9]1[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=1.[Cl:16][C:17]1[CH:18]=[C:19](B(O)O)[CH:20]=[CH:21][CH:22]=1>>[Cl:16][C:17]1[CH:22]=[C:21]([C:2]2[N:7]=[N:6][C:5]([NH2:8])=[N:4][C:3]=2[C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=2)[CH:20]=[CH:19][CH:18]=1

참가 물질

반응물 2

HCID 2734323(3-Chlorophenyl)boronic acid

HCID 866761176-Bromo-5-(4-fluorophenyl)-1,2,4-triazin-3-amine

생성물 1

HCID 53354726HCID 53354726, 화합물수율 19.5%

실험 절차

6-(3-Chlorophenyl)-5-(4-fluorophenyl)-1,2,4-triazin-3-amine (65.0 mg, 19%) was prepared from 6-bromo-5-(4-fluorophenyl)-1,2,4-triazin-3-amine (0.30 g, 1.11 mmol) and 3-chlorophenylboronic acid (0.19 g, 1.23 mmol) according to the general procedure of Example 1.

출처 및 근거

ORD 기록: ord-1aa65a0e75d24148815011ff6342aad3
출처 데이터셋: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08809525B2

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