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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Trifluoroacetic acid → 4-(2-((Tert-butyldimethylsilyl)oxy)ethyl)piperidin-1-amine 2,2,2-trifluoroacetate

HRID 240716
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인쇄 미리보기

반응식

HRID 240716 반응식
C(OC(=O)[NH:7][N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][CH2:15][O:16][Si:17]([C:20]([CH3:23])([CH3:22])[CH3:21])([CH3:19])[CH3:18])[CH2:10][CH2:9]1)(C)(C)C.[F:25][C:26]([F:31])([F:30])[C:27]([OH:29])=[O:28]>ClCCl>[F:25][C:26]([F:31])([F:30])[C:27]([OH:29])=[O:28].[C:20]([Si:17]([CH3:19])([CH3:18])[O:16][CH2:15][CH2:14][CH:11]1[CH2:12][CH2:13][N:8]([NH2:7])[CH2:9][CH2:10]1)([CH3:22])([CH3:21])[CH3:23]
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참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 71294244{4-[2-(t-Butyl-dimethyl-silanyloxy)-ethyl]-piperidin-1-yl}-carbamic acid t-butyl ester

생성물 1

HCID 712943124-(2-((Tert-butyldimethylsilyl)oxy)ethyl)piperidin-1-amine 2,2,2-trifluoroacetate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
0 °C

실험 절차

{4-[2-(t-Butyl-dimethyl-silanyloxy)-ethyl]-piperidin-1-yl}-carbamic acid t-butyl ester (168 mg, 468 μmol) was at 0° C. combined with dichloromethane (2 mL) and trifluoroacetic acid (2 mL) to give a light yellow solution. The reaction mixture was stirred for 2 h at 0° C. and subsequently concentrated in vacuo to give the title compound as yellow oil, which was used without further purification in the next step.

후처리

  1. customwas at 0° C.
  2. customto give a light yellow solution
  3. concentrationsubsequently concentrated in vacuo

출처 및 근거

ORD 기록
ord-11ca2491e15a4044899419874d6dfd67
출처 데이터셋
uspto-grants-2014_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08648099B2

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