[5-(2-PYRIDINYL)-2-THIENYL]METHANOL → 5-(Pyridin-2-yl)thiophene-2-carbaldehyde

HRID 2407664노트

반응식

HRID 2407664 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[S:11][C:10]([CH2:12][OH:13])=[CH:9][CH:8]=1>O1CCCC1.[O-2].[O-2].[Mn+4]>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[S:11][C:10]([CH:12]=[O:13])=[CH:9][CH:8]=1

참가 물질

4

반응물 1

HCID 2776202[5-(2-PYRIDINYL)-2-THIENYL]METHANOL

생성물 1

HCID 6051275-(Pyridin-2-yl)thiophene-2-carbaldehyde수율 8,307.6%

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 8028Tetrahydrofuran용매

실험 절차

A solution of (5-(pyridin-2-yl)thien-2-yl) methanol (0.100 g) and manganese dioxide (0.136 g) in tetrahydrofuran (3.5 mL) was refluxed overnight. The mixture was cooled to room temperature and the solids were filtered. The filtrate was concentrated and the residue was triturated (hexane:diethyl ether=1:1) to obtain the title compound (8.22 g) having the following physical data.

후처리

  1. filtrationthe solids were filtered
  2. concentrationThe filtrate was concentrated
  3. customthe residue was triturated (hexane:diethyl ether=1:1)

출처 및 근거

ORD 기록
ord-27bbdf48b6e240269cf7de43153fb030
출처 데이터셋
uspto-grants-2014_08
특허 번호
US08809538B2

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