2-Chloronicotinic acid → 2-Ethoxypyridine-3-carboxylic acid

HRID 2407767노트

반응식

HRID 2407767 반응식
[O-:1][CH2:2][CH3:3].[Na+].Cl[C:6]1[N:14]=[CH:13][CH:12]=[CH:11][C:7]=1[C:8]([OH:10])=[O:9]>C(O)C>[CH2:2]([O:1][C:6]1[N:14]=[CH:13][CH:12]=[CH:11][C:7]=1[C:8]([OH:10])=[O:9])[CH3:3]

참가 물질

4

반응물 2

HCID 762582-Chloronicotinic acidHCID 2723922Sodium ethoxide

생성물 1

HCID 27363452-Ethoxypyridine-3-carboxylic acid

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
170 °C

실험 절차

A solution of sodium ethoxide (14.2 mL) was added to a solution of 2-chloronicotinic acid (2.00 g) in ethanol (13 mL). The mixture was heated in a sealed vessel at 170° C. for 2 days. After cooling, the mixture was concentrated in vacuo and the residue taken in water and acidified with hydrochloric acid to pH 3. The precipitated solids were collected by filtration and washed with water to obtain the title compound (1.32 g) having the following physical data.

후처리

  1. temperatureAfter cooling
  2. concentrationthe mixture was concentrated in vacuo
  3. filtrationThe precipitated solids were collected by filtration
  4. washwashed with water

출처 및 근거

ORD 기록
ord-dc62b7633eaa408eb8d62e494388d43c
출처 데이터셋
uspto-grants-2014_08
특허 번호
US08809538B2

반응 노트

불러오는 중…