Sodium Chloride → HCID 58503970, 화합물

HRID 2407792노트

반응식

HRID 2407792 반응식
[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([O:10][CH2:11][CH3:12])[N:5]=[C:4]([C:13]([NH:15][CH2:16][CH:17]2[CH2:22][CH2:21][N:20](C(OC(C)(C)C)=O)[CH2:19][CH2:18]2)=[O:14])[CH:3]=1.FC(F)(F)C(O)=O.C(=O)(O)[O-].[Na+].[Cl-].[Na+]>ClCCl.C(OCC)(=O)C>[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([O:10][CH2:11][CH3:12])[N:5]=[C:4]([C:13]([NH:15][CH2:16][CH:17]2[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]2)=[O:14])[CH:3]=1

참가 물질

7

반응물 4

HCID 5234Sodium ChlorideHCID 6422Trifluoroacetic acidHCID 516892Sodium BicarbonateHCID 58504102HCID 58504102, 화합물

생성물 1

HCID 58503970HCID 58503970, 화합물수율 102.3%

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 8857Ethyl Acetate용매

실험 절차

The compound prepared in Example 225 (3.579 g) was suspended in dichloromethane (50 mL) and trifluoroacetic acid (10.00 mL) added and the reaction mixture stirred at room temperature for 2 hours. The reaction mixture was poured onto saturated aqueous sodium bicarbonate and ethyl acetate. The aqueous layer was saturated with sodium chloride. The desired material crystallized from the aqueous and was isolated by filtration to obtain the title compound (2.752 g) with the following physical data.

후처리

  1. customThe desired material crystallized from the aqueous and
  2. customwas isolated by filtration

출처 및 근거

ORD 기록
ord-20ae0b4ed24d4ddbaf96d19cd1481ed5
출처 데이터셋
uspto-grants-2014_08
특허 번호
US08809538B2

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