HCID 58504050, 화합물 → 1-(2-pyridin-2-yl-1,3-thiazol-5-yl)ethanone

HRID 2407797노트

반응식

HRID 2407797 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[S:8][C:9]([CH:12]([OH:14])[CH3:13])=[CH:10][N:11]=1>ClCCl.[O-2].[Mn+4].[O-2]>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[S:8][C:9]([C:12](=[O:14])[CH3:13])=[CH:10][N:11]=1

참가 물질

4

반응물 1

HCID 58504050HCID 58504050, 화합물

생성물 1

HCID 27682031-(2-pyridin-2-yl-1,3-thiazol-5-yl)ethanone수율 94.9%

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 6344Dichloromethane용매

실험 절차

The compound prepared in Example 357 (2.5 g) was dissolved in 80 mL of dichloromethane and manganese (IV) oxide (21 g) was added stirred overnight at room temperature. The reaction mixture was filtered through a plug of Celite (trade mark), washed with dichloromethane, and concentrated under reduced pressure to afford the title compound (2.35 g) having the following physical data. 1H NMR (CDCl3): δ 8.64 (d, J=4.5 Hz, 1H), 8.39 (s, 1H), 8.22 (d, J=7.9 Hz, 1H), 7.83 (m, 1H), 7.39 (m, 1H), 2.62 (s, 3H).

후처리

  1. filtrationThe reaction mixture was filtered through a plug of Celite (trade mark)
  2. washwashed with dichloromethane
  3. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-e57a1c6a15e548039db900719452fcdb
출처 데이터셋
uspto-grants-2014_08
특허 번호
US08809538B2

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