Water → Methyl 4-amino-5,6-dichloropicolinate
반응식
[NH2:1][C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[C:4]([C:9]([O:11][CH3:12])=[O:10])[CH:3]=1.[Cl:13]N1C(=O)CCC1=O.C(=O)(O)[O-].[Na+].O>CN(C)C=O>[NH2:1][C:2]1[C:7]([Cl:13])=[C:6]([Cl:8])[N:5]=[C:4]([C:9]([O:11][CH3:12])=[O:10])[CH:3]=1참가 물질
6
반응 조건
- 온도
- 50 °C
실험 절차
The compound prepared in Example 404 (3.120 g) and N-chlorosuccinimide (2.456 g) were suspended in dimethyl formamide (100 mL) and stirred at 50° C. overnight. The reaction mixture was heated at 70° C. for a further 3 hours. The reaction mixture was added drop-wise to a stirred solution of 1:1 saturated aqueous sodium bicarbonate and water. The slurry was filtered and the solids dried under high vacuum to furnish the title compound (2.438 g), possessing the following physical data.
후처리
- temperatureThe reaction mixture was heated at 70° C. for a further 3 hours
- filtrationThe slurry was filtered
- customthe solids dried under high vacuum
출처 및 근거
- ORD 기록
- ord-93104871107f402da7d82396c220118d
- 출처 데이터셋
- uspto-grants-2014_08
- 특허 번호
- US08809538B2
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