Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 2408336생성일: 2026년 10월 26일
Phosphorus oxychloride → 7-chloro-2,2-dimethyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1H)-one
https://huagongshe.com/reaction/2408336
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Phosphorus oxychloride | HCID 24813 | — |
| 반응물 | 7-hydroxy-2,2-dimethyl-2,3-dihydro-1H-imidazo[1,2-a]pyrimidin-5-one | HCID 136269314 | — |
| 용매 | 1,1-Dichloroethane | HCID 6365 | — |
| 생성물 | 7-chloro-2,2-dimethyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1H)-one | HCID 136359100 | 83% |
반응 단계
18.5 g of 7-hydroxy-2,2-dimethyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1H)-one are suspended in 200 mL of dichloroethane. 48 mL of POCl3 are added and the mixture is heated to 60° C. for 3 h. After returning to RT, the solvents are dry evaporated. The residue is taken up in water and AcOET, 30% NaOH is added until pH=12. The product precipitates, it is filtered and then dried. 16.9 g (yield=83%) of 7-chloro-2,2-dimethyl-2,3-dihydroimidazo[1,2-a]pyrimidin-5(1H)-one are obtained as a yellow solid and including the following characteristics:
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08815853B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_08 |
|---|
| ORD ID | ord-cfbad2d59f32478b9814e43839378362 |
|---|
| 출처 메모 | uspto-grants-2014_08 |
|---|
