Ethyl Acetate → D-Alloisoleucine, methyl ester
반응식
Cl.[NH2:2][C@@H:3]([C:8]([O:10][CH3:11])=[O:9])[C@H:4]([CH2:6][CH3:7])[CH3:5].C(OCC)(=O)C.C(=O)([O-])[O-].[K+].[K+]>O>[NH2:2][C@@H:3]([C:8]([O:10][CH3:11])=[O:9])[C@H:4]([CH2:6][CH3:7])[CH3:5]참가 물질
5
실험 절차
Methyl d-alloisoleucinate hydrochloride (Compound 2) was charged to ethyl acetate. A solution of potassium carbonate in water was then added. The mixture was then stirred vigorously at room temperature for 1 hour. The two layers were separated and the aqueous layer further extracted with ethyl acetate. The organic layers were combined and washed with brine. The organic layers were then concentrated in vacuo and filtered to yield methyl D-alloisoleucinate (Compound 3) as a pale yellow oil.
후처리
- customThe two layers were separated
- extractionthe aqueous layer further extracted with ethyl acetate
- washwashed with brine
- concentrationThe organic layers were then concentrated in vacuo
- filtrationfiltered
출처 및 근거
- ORD 기록
- ord-847d661b01ab47c6a51ffa0babd7c4b3
- 출처 데이터셋
- uspto-grants-2014_08
- 특허 번호
- US08815856B2
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