Oxalyl chloride → 2-Acetoxypropionyl Chloride

HRID 240894

반응식

[C:1]([O:4][CH:5]([CH3:9])[C:6](O)=[O:7])(=[O:3])[CH3:2].C(Cl)(=O)C([Cl:13])=O>>[C:1]([O:4][CH:5]([CH3:9])[C:6]([Cl:13])=[O:7])(=[O:3])[CH3:2]

참가 물질

반응물 2

HCID 65578Oxalyl chloride

HCID 790412-Acetoxypropionic Acid

생성물 1

HCID 45474922-Acetoxypropionyl Chloride

실험 절차

Stir a mixture of 2-acetoxy-propionic acid (550 g, 4.16 mol) in oxalyl chloride (500 mL) at room temperature for overnight. After removal of oxalyl chloride under vacuum, ˜700 g crude product is obtained (quantitative yield crude), which is used directly in the next step. 1H NMR (CDCl3, 400 MHz): δ 5.16 (m, 1H), 2.13 (s, 3H), 1.58 (d, J=7.2, 3H).

후처리

customAfter removal of oxalyl chloride under vacuum

출처 및 근거

ORD 기록: ord-d1f45a29329b409e8b9910c2a4ebf546
출처 데이터셋: uspto-grants-2014_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08648081B2

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