Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Chloro-5-nitropyridin-4-amine → 6-Chloropyridine-3,4-diamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Chloro-5-nitropyridin-4-amine | HCID 10910058 | — |
| 촉매 | Nickel | HCID 935 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 6-Chloropyridine-3,4-diamine | HCID 817133 | 107.4% |
반응 단계
To a solution of 2-chloro-5-nitropyridin-4-amine (4.50 g, 25.93 mmol) in EtOAc (100 mL) was added Raney nickel (0.45 g) followed by stirring under hydrogen at RT for 2 h. The reaction mixture was filtered and the filtrate concentrated under reduced pressure to afford 4.00 g (ca. 100%) of crude 6-chloropyridine-3,4-diamine as yellow oil. MS (ESI): m/z=144.3 [M+1]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08815877B2 |
| 출처 데이터셋 | uspto-grants-2014_08 |
| ORD ID | ord-6be8b6661d27469f9649a4b31d83a784 |
| 출처 메모 | uspto-grants-2014_08 |