tert-butyl N-(methylcarbamothioyl)carbamate → [(S)-1,4-dimethyl-4-(3-nitro-phenyl)-6-oxo-1,4,5,6-tetrahydro-pyrimidin-2-yl]-carbamic acid tert-butyl ester

HRID 2409119노트

반응식

HRID 2409119 반응식
CO[C:3](=[O:17])[CH2:4][C@:5]([NH2:16])([C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([N+:13]([O-:15])=[O:14])[CH:8]=1)[CH3:6].[CH3:18][NH:19][C:20]([NH:22][C:23](=[O:29])[O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=S>>[C:25]([O:24][C:23](=[O:29])[NH:22][C:20]1[N:19]([CH3:18])[C:3](=[O:17])[CH2:4][C@@:5]([CH3:6])([C:7]2[CH:12]=[CH:11][CH:10]=[C:9]([N+:13]([O-:15])=[O:14])[CH:8]=2)[N:16]=1)([CH3:28])([CH3:27])[CH3:26]

참가 물질

3

반응물 2

HCID 57496573tert-butyl N-(methylcarbamothioyl)carbamateHCID 57505082(S)-3-amino-3-(3-nitro-phenyl)-butyric acid methyl ester

생성물 1

HCID 57496576[(S)-1,4-dimethyl-4-(3-nitro-phenyl)-6-oxo-1,4,5,6-tetrahydro-pyrimidin-2-yl]-carbamic acid tert-butyl ester

실험 절차

Starting from (S)-3-amino-3-(3-nitro-phenyl)-butyric acid methyl ester and tert-butyl [(methylamino)carbonothioyl]carbamate, the product [(S)-1,4-dimethyl-4-(3-nitro-phenyl)-6-oxo-1,4,5,6-tetrahydro-pyrimidin-2-yl]-carbamic acid tert-butyl ester was obtained as white solid. MS (ESI): m/z=361.4 [M−H]−.

출처 및 근거

ORD 기록
ord-7fd3c1c2bdbc43aa80efd01a12c6705a
출처 데이터셋
uspto-grants-2014_08
특허 번호
US08815881B2

반응 노트

불러오는 중…