Anisole → HCID 71178940, 화합물

HRID 2409268노트

반응식

HRID 2409268 반응식
C([NH:5][S:6]([C:9]1[CH:10]=[N:11][N:12]2[C:17]([NH:18][C:19]3[CH:24]=[CH:23][C:22]([F:25])=[CH:21][C:20]=3[CH3:26])=[C:16]([C:27]([N:29]3[CH2:34][CH2:33][CH:32]([C:35]4[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=4)[CH2:31][CH2:30]3)=[O:28])[CH:15]=[N:14][C:13]=12)(=[O:8])=[O:7])(C)(C)C.C1(OC)C=CC=CC=1>FC(F)(F)C(O)=O>[F:25][C:22]1[CH:23]=[CH:24][C:19]([NH:18][C:17]2[N:12]3[N:11]=[CH:10][C:9]([S:6]([NH2:5])(=[O:8])=[O:7])=[C:13]3[N:14]=[CH:15][C:16]=2[C:27]([N:29]2[CH2:34][CH2:33][CH:32]([C:35]3[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=3)[CH2:31][CH2:30]2)=[O:28])=[C:20]([CH3:26])[CH:21]=1

참가 물질

4

반응물 2

HCID 7519AnisoleHCID 71178956HCID 71178956, 화합물

생성물 1

HCID 71178940HCID 71178940, 화합물수율 56.1%

시약·촉매·용매 1

HCID 6422Trifluoroacetic acid용매

실험 절차

N-tert-Butyl-7-(4-fluoro-2-methylphenylamino)-6-(4-phenylpiperidine-1-carbonyl)pyrazolo[1,5-a]pyrimidine-3-sulfonamide (0.874 g, 1.548 mmol) obtained in step 4 was dissolved in trifluoroacetic acid (13 mL), anisole (0.4 mL) was added, and the mixture was stirred at room temperature overnight. The reaction mixture was concentrated under reduced pressure, the obtained residue was purified by silica gel column chromatography (chloroform/methanol=10/1) to give the title compound (0.442 g, 56%).

후처리

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customthe obtained residue was purified by silica gel column chromatography (chloroform/methanol=10/1)

출처 및 근거

ORD 기록
ord-faf5461726e74e87b749c5b3c604b24b
출처 데이터셋
uspto-grants-2014_08
특허 번호
US08815874B2

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