HCID 58424985, 화합물 → Ethyl 3-amino-5-methoxybenzoate
반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:11]=[C:12]([N+:14]([O-])=O)[CH:13]=1)[C:6]([O:8][CH2:9][CH3:10])=[O:7].[H][H]>C(OCC)(=O)C.[Pd]>[NH2:14][C:12]1[CH:11]=[C:5]([CH:4]=[C:3]([O:2][CH3:1])[CH:13]=1)[C:6]([O:8][CH2:9][CH3:10])=[O:7]참가 물질
5
실험 절차
The compound (5.1 g, 23.1 mmol) prepared in step 2 was dissolved in ethyl acetate (50.0 ml), added with 10%-palladium (Pd) (100 mg). The resulting mixture was then stirred at room temperature for 24 hours in presence of hydrogen gas. After completion, 10%-palladium (Pd) was removed by celite-filter and the filtrate concentrated to dryness. The residue was purified by flash column chromatography (hexane:ethyl acetate=2:1) to obtain the title compound (4.36 g, yield: 96.8%, white solid).
후처리
- customAfter completion, 10%-palladium (Pd) was removed
- filtrationby celite-filter
- concentrationthe filtrate concentrated to dryness
- customThe residue was purified by flash column chromatography (hexane:ethyl acetate=2:1)
출처 및 근거
- ORD 기록
- ord-0b8b5abadc8b4decabf1467fd024c965
- 출처 데이터셋
- uspto-grants-2014_08
- 특허 번호
- US08815891B2
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