1-(3,4-dimethylphenyl)-3-nitro-1H-pyrazole → 1-(3,4-dimethylphenyl)-1H-pyrazol-3-amine
반응식
[CH3:1][C:2]1[CH:3]=[C:4]([N:9]2[CH:13]=[CH:12][C:11]([N+:14]([O-])=O)=[N:10]2)[CH:5]=[CH:6][C:7]=1[CH3:8]>CO.C(OCC)(=O)C.[Pd]>[CH3:1][C:2]1[CH:3]=[C:4]([N:9]2[CH:13]=[CH:12][C:11]([NH2:14])=[N:10]2)[CH:5]=[CH:6][C:7]=1[CH3:8]참가 물질
4
실험 절차
Into a 100-mL round bottom flask, was placed a solution of 1-(3,4-dimethylphenyl)-3-nitro-1H-pyrazole (900 mg, 4.15 mmol, 1.00 equiv) in methanol/ethyl acetate (20/10 mL). The solution was treated with Pd/C (500 mg) and stirred under an atmosphere of hydrogen overnight at room temperature. The reaction progress was monitored by LCMS. The solids were filtered out. The resulting mixture was concentrated under vacuum to yield 750 mg (97%) of 1-(3,4-dimethylphenyl)-1H-pyrazol-3-amine as a yellow solid.
후처리
- customInto a 100-mL round bottom flask, was placed
- filtrationThe solids were filtered out
- concentrationThe resulting mixture was concentrated under vacuum
출처 및 근거
- ORD 기록
- ord-0ebfb1ba27e444d796a049035d156184
- 출처 데이터셋
- uspto-grants-2014_08
- 특허 번호
- US08815910B2
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