1-(4-bromophenyl)-1H-pyrazole → 1-(4-(1H-Pyrazol-1-yl)phenyl)piperidin-3-one

HRID 2409883노트

반응식

HRID 2409883 반응식
BrC1C=CC(N2C=CC=N2)=CC=1.[N:13]1([C:18]2[CH:23]=[CH:22][C:21]([N:24]3[CH2:29][CH2:28][CH2:27][CH:26]([OH:30])[CH2:25]3)=[CH:20][CH:19]=2)[CH:17]=[CH:16][CH:15]=[N:14]1>>[N:13]1([C:18]2[CH:19]=[CH:20][C:21]([N:24]3[CH2:29][CH2:28][CH2:27][C:26](=[O:30])[CH2:25]3)=[CH:22][CH:23]=2)[CH:17]=[CH:16][CH:15]=[N:14]1

참가 물질

3

반응물 2

HCID 104435641-(4-bromophenyl)-1H-pyrazoleHCID 712273821-(4-(1H-pyrazol-1-yl)phenyl)piperidin-3-ol

생성물 1

HCID 712273561-(4-(1H-Pyrazol-1-yl)phenyl)piperidin-3-one

실험 절차

1-(4-(1H-Pyrazol-1-yl)phenyl)piperidin-3-one (300 mg, 1.243 mmol) was synthesized as described in General Procedure B using 1-(4-bromophenyl)-1H-pyrazole. The resulting product 1-(4-(1H-pyrazol-1-yl)phenyl)piperidin-3-ol was oxidized using General Procedure D to give the title compound.

후처리

  1. customto give the title compound

출처 및 근거

ORD 기록
ord-73d5ac17ea5d4d25bb177105f627bb8a
출처 데이터셋
uspto-grants-2014_08
특허 번호
US08815909B2

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