4,6-Dichloro-5-methylpyrimidine → 4-Chloro-5-methyl-6-(phenylmethyl)pyrimidine

HRID 240993

반응식

HRID 240993 반응식
[Cl:1][C:2]1[C:7]([CH3:8])=[C:6](Cl)[N:5]=[CH:4][N:3]=1.[Br-].[CH2:11]([Zn+])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>>[Cl:1][C:2]1[C:7]([CH3:8])=[C:6]([CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[N:5]=[CH:4][N:3]=1

참가 물질

3

반응물 2

HCID 8188604,6-Dichloro-5-methylpyrimidineHCID 178419772HCID 178419772, 화합물

생성물 1

HCID 866478104-Chloro-5-methyl-6-(phenylmethyl)pyrimidine

실험 절차

Prepared from 4,6-dichloro-5-methylpyrimidine and benzyl zinc bromide (0.5 M solution in tetrahydrofuran) according to the procedure described in WO 2007/146824 as a colorless oil. 1H NMR (400 MHz, CDCl3): 8.78 (s, 1H), 7.33-7.18 (m, 5H), 4.19 (s, 2H), 2.36 (s, 3H); MS (EI) for C12H11ClN2: 219 (MH+).

출처 및 근거

ORD 기록
ord-99aad49d6c514068be450f3affc03e1c
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08648066B2

연결된 노트

불러오는 중…