3-Chloroaniline → HCID 86707780, 화합물

HRID 2410136노트

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HRID 2410136 반응식
[CH2:1]([O:3][C:4]([C:6]1[N:7]=[C:8]([Br:24])[N:9]([CH:21]([CH3:23])[CH3:22])[C:10]=1[CH:11]([C:13]1[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:14]=1[CH3:20])O)=[O:5])[CH3:2].[Cl:25][C:26]1[CH:27]=[C:28]([CH:30]=[CH:31][CH:32]=1)[NH2:29]>C(Cl)Cl.O>[CH2:1]([O:3][C:4]([C:6]1[N:7]=[C:8]([Br:24])[N:9]([CH:21]([CH3:23])[CH3:22])[C:10]=1[CH:11]([C:13]1[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][C:14]=1[CH3:20])[NH:29][C:28]1[CH:30]=[CH:31][CH:32]=[C:26]([Cl:25])[CH:27]=1)=[O:5])[CH3:2]

참가 물질

4

반응물 2

HCID 79323-ChloroanilineHCID 86707752HCID 86707752, 화합물

생성물 1

HCID 86707780HCID 86707780, 화합물

시약·촉매·용매 1

HCID 21908982Water methylene chloride용매

실험 절차

The title compound was prepared in analogy to the procedure described for step E2 with the intermediate C and the 3-chloroaniline. The reaction mixture was diluted in DCM/water and the phases were separated. The organic phase was dried (Na2SO4) and concentrated. The product was purified by flash chromatography (heptane/EtOAc, 9:1) to give the title compound. tR: 1.47 min (LC-MS 2); ESI-MS: 524.0/526.0/528.2 [M+H]+ (LC-MS 2).

후처리

  1. customThe title compound was prepared in analogy to the procedure
  2. customthe phases were separated
  3. dry with materialThe organic phase was dried (Na2SO4)
  4. concentrationconcentrated
  5. customThe product was purified by flash chromatography (heptane/EtOAc, 9:1)

출처 및 근거

ORD 기록
ord-f35b6beeccf741868f98740febbe1eaf
출처 데이터셋
uspto-grants-2014_08
특허 번호
US08815926B2

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