홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Sodium Bicarbonate → Methyl 1-{[4-({[4-(2,2,2-trifluoroethoxy)-1,2-benzisoxazol-3-yl]oxy}methyl)piperidin-1-yl]methyl}-cyclobutanecarboxylate

HRID 2410325
노트
인쇄 미리보기

반응식

HRID 2410325 반응식
[NH:1]1[CH2:6][CH2:5][CH:4]([CH2:7][O:8][C:9]2[C:13]3[C:14]([O:18][CH2:19][C:20]([F:23])([F:22])[F:21])=[CH:15][CH:16]=[CH:17][C:12]=3[O:11][N:10]=2)[CH2:3][CH2:2]1.[CH:24]([C:26]1([C:30]([O:32][CH3:33])=[O:31])[CH2:29][CH2:28][CH2:27]1)=O.C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+].C(=O)([O-])O.[Na+]>ClCCl>[F:23][C:20]([F:21])([F:22])[CH2:19][O:18][C:14]1[C:13]2[C:9]([O:8][CH2:7][CH:4]3[CH2:5][CH2:6][N:1]([CH2:24][C:26]4([C:30]([O:32][CH3:33])=[O:31])[CH2:29][CH2:28][CH2:27]4)[CH2:2][CH2:3]3)=[N:10][O:11][C:12]=2[CH:17]=[CH:16][CH:15]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 516892Sodium BicarbonateHCID 5049666Sodium triacetoxyborohydrideHCID 15656335Methyl 1-formylcyclobutane-1-carboxylateHCID 693177283-(Piperidin-4-ylmethoxy)-4-(2,2,2-trifluoroethoxy)-1,2-benzisoxazole

생성물 1

HCID 69316237Methyl 1-{[4-({[4-(2,2,2-trifluoroethoxy)-1,2-benzisoxazol-3-yl]oxy}methyl)piperidin-1-yl]methyl}-cyclobutanecarboxylate

시약·촉매·용매

1
HCID 6344Dichloromethane용매

실험 절차

To a stirred mixture of 3-(piperidin-4-ylmethoxy)-4-(2,2,2-trifluoroethoxy)-1,2-benzisoxazole (0.33 g, 1.0 mmol, EXAMPLE 2, Step 2) and methyl 1-formylcyclobutanecarboxylate (0.17 g, 1.2 mmol, J. Org. Chem. 1993, 58, 6843-6850) in dichloromethane (5 mL) was added sodium triacetoxyborohydride (0.42 g, 2.0 mmol) at room temperature. After being stirred at room temperature for 16 h, sat. aq. sodium hydrogencarbonate (20 mL) was added to the mixture. The mixture was extracted with dichloromethane (30 mL×2). The combined extract was dried over magnesium sulfate and concentrated in vacuo to give 0.46 g (quant.) of the title compound as a colorless oil.

후처리

  1. extractionThe mixture was extracted with dichloromethane (30 mL×2)
  2. extractionThe combined extract
  3. dry with materialwas dried over magnesium sulfate
  4. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-7a57f0cefc7c4291a53574b4c1dc5767
출처 데이터셋
uspto-grants-2014_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08816090B2

반응 노트

불러오는 중…

이 페이지에서참가 물질실험 절차후처리출처 및 근거반응 노트