Methyl 2,2-dimethyl-3-oxopropanoate → HCID 69319055, 화합물

HRID 2410339노트

반응식

HRID 2410339 반응식
[CH2:1]([O:5][C:6]1[C:11]2[C:12]([O:15][CH2:16][CH:17]3[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]3)=[N:13][O:14][C:10]=2[CH:9]=[CH:8][CH:7]=1)[CH:2]([CH3:4])[CH3:3].[CH3:23][C:24]([CH3:31])([CH:29]=O)[C:25]([O:27][CH3:28])=[O:26].C(C1(C(OC)=O)CCC1)=O>>[CH2:1]([O:5][C:6]1[C:11]2[C:12]([O:15][CH2:16][CH:17]3[CH2:22][CH2:21][N:20]([CH2:23][C:24]([CH3:31])([CH3:29])[C:25]([O:27][CH3:28])=[O:26])[CH2:19][CH2:18]3)=[N:13][O:14][C:10]=2[CH:9]=[CH:8][CH:7]=1)[CH:2]([CH3:4])[CH3:3]

참가 물질

4

반응물 3

HCID 11137194Methyl 2,2-dimethyl-3-oxopropanoateHCID 15656335Methyl 1-formylcyclobutane-1-carboxylateHCID 693169774-Isobutoxy-3-(piperidin-4-ylmethoxy)-1,2-benzisoxazole

생성물 1

HCID 69319055HCID 69319055, 화합물

실험 절차

The title compound was prepared according to the procedure described in Step 3 of EXAMPLE 2 using 4-isobutoxy-3-(piperidin-4-ylmethoxy)-1,2-benzisoxazole (EXAMPLE 10, Step 1) and methyl 2,2-dimethyl-3-oxopropanoate (0.96 mg, 0.74 mmol, Tetrahedron Asymmetry 2003, 14, 3371-3378) instead of 3-(piperidin-4-ylmethoxy)-4-(2,2,2-trifluoroethoxy)-1,2-benzisoxazole and methyl 1-formylcyclobutanecarboxylate.

출처 및 근거

ORD 기록
ord-c8fe35b51dc44c169d9c8147793e397e
출처 데이터셋
uspto-grants-2014_08
특허 번호
US08816090B2

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