Ethanolamine → 5-bromo-N-(2-hydroxyethyl)-2-(methylamino)pyridine-3-sulfonamide

HRID 241043노트

반응식

HRID 241043 반응식
[Br:1][C:2]1[CH:3]=[C:4]([S:10](Cl)(=[O:12])=[O:11])[C:5]([NH:8][CH3:9])=[N:6][CH:7]=1.BrC1C=CC(NC)=NC=1.[NH2:23][CH2:24][CH2:25][OH:26]>>[Br:1][C:2]1[CH:3]=[C:4]([S:10]([NH:23][CH2:24][CH2:25][OH:26])(=[O:12])=[O:11])[C:5]([NH:8][CH3:9])=[N:6][CH:7]=1

참가 물질

4

반응물 3

HCID 700EthanolamineHCID 156456635-Bromo-N-methylpyridin-2-amineHCID 866478215-Bromo-2-(methylamino)pyridine-3-sulfonyl chloride

생성물 1

HCID 668205615-bromo-N-(2-hydroxyethyl)-2-(methylamino)pyridine-3-sulfonamide

실험 절차

Prepared according to the methods described in reagent preparation 25 using 5-bromo-2-(methylamino)pyridine-3-sulfonyl chloride (prepared from 5-bromo-N-methylpyridin-2-amine using analogous conditions to those described in WO2008144463) and 2-aminoethanol in step 1.

후처리

  1. customPrepared

출처 및 근거

ORD 기록
ord-10afbe0e984e40d791253d8fe910203b
출처 데이터셋
uspto-grants-2014_02
특허 번호
US08648066B2

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