Cetyl Alcohol → Hexadecyl cis-10-tetradecenoate

HRID 2410629

반응식

HRID 2410629 반응식
[CH2:1]([OH:17])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16]>CCCCCC>[C:1]([O:17][CH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16])(=[O:17])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9]/[CH:10]=[CH:11]\[CH2:12][CH2:13][CH3:14]

참가 물질

3

반응물 1

HCID 2682Cetyl Alcohol

생성물 1

HCID 46700773Hexadecyl cis-10-tetradecenoate수율 80%

시약·촉매·용매 1

HCID 8058Hexane용매

실험 절차

cis-10-Myristoleate, 7 (3.35 g, 0.014 mol) was enzymatically transesterified with cetyl alcohol (4.07 g, 0.0168 mol) in the presence of Novozyme 435 (0.745 g, 10 wt % of the total substrate), at 65 degree. C for 8 hr. The reaction was monitored by TLC and after completion of reaction, hexane (50 ml) was added and the lipase was separated by filtration and the solvent was evaporated to get the crude product and was purified by column chromatography to obtain hexadecyl cis-10-tetradecenoate, 8 (5.55 g, 0.0123) in 80% yield with 90% purity by GC. The structure of hexadecyl cis-10-tetradecenoate, 8 was confirmed by 1H NMR, IR, and GC-MS.

후처리

  1. customat 65 degree
  2. additionwas added
  3. customthe lipase was separated by filtration
  4. customthe solvent was evaporated
  5. customto get the crude product
  6. customwas purified by column chromatography

출처 및 근거

ORD 기록
ord-deca41be93d144a6b20eb59af18c29ee
출처 데이터셋
uspto-grants-2014_08
특허 번호
US08816109B2

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