Ammonia → 2-Amino-5-bromopyridine-3-sulfonamide
반응식
[NH2:1][C:2]1[C:7]([S:8](Cl)(=[O:10])=[O:9])=[CH:6][C:5]([Br:12])=[CH:4][N:3]=1.[NH3:13]>O1CCOCC1>[NH2:1][C:2]1[C:7]([S:8]([NH2:13])(=[O:10])=[O:9])=[CH:6][C:5]([Br:12])=[CH:4][N:3]=1참가 물질
4
실험 절차
2-Amino-5-bromopyridine-3-sulfonyl chloride (reagent preparation 25) (95.5 mg, 0.35 mmol) was treated with 0.5M ammonia in dioxane solution (7 mL) and the mixture was stirred for 1 h at room temperature. Concentrated aqueous ammonia (2 mL) was then added to the mixture then stirred an additional 12 h. The mixture was then concentrated and the residue suspended in water (5 mL). The solid was collected by filtration and dried to give 2-amino-5-bromopyridine-3-sulfonamide (55.7 mg, 89%).
후처리
- stirringthen stirred an additional 12 h
- concentrationThe mixture was then concentrated
- filtrationThe solid was collected by filtration
- customdried
출처 및 근거
- ORD 기록
- ord-e5320d8f4f554ff1ad962cc3902c6112
- 출처 데이터셋
- uspto-grants-2014_02
- 특허 번호
- US08648066B2
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