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Morpholine, 4-[[2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl]- → 3-(3-chloro-4-(morpholinomethyl)phenyl)-7-(pyridin-3-yl)-9H-carbazole-1-carboxamide

HRID 2410920
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인쇄 미리보기

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HRID 2410920 반응식
Br[C:2]1[CH:3]=[C:4]([C:21]([NH2:23])=[O:22])[C:5]2[NH:6][C:7]3[C:12]([C:13]=2[CH:14]=1)=[CH:11][CH:10]=[C:9]([C:15]1[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=1)[CH:8]=3.[Cl:24][C:25]1[CH:37]=[C:36](B2OC(C)(C)C(C)(C)O2)[CH:35]=[CH:34][C:26]=1[CH2:27][N:28]1[CH2:33][CH2:32][O:31][CH2:30][CH2:29]1>C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2].C(Cl)Cl>[Cl:24][C:25]1[CH:37]=[C:36]([C:2]2[CH:3]=[C:4]([C:21]([NH2:23])=[O:22])[C:5]3[NH:6][C:7]4[C:12]([C:13]=3[CH:14]=2)=[CH:11][CH:10]=[C:9]([C:15]2[CH:16]=[N:17][CH:18]=[CH:19][CH:20]=2)[CH:8]=4)[CH:35]=[CH:34][C:26]=1[CH2:27][N:28]1[CH2:29][CH2:30][O:31][CH2:32][CH2:33]1
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참가 물질

4

반응물 2

HCID 59392678Morpholine, 4-[[2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl]-HCID 666059313-bromo-7-(pyridin-3-yl)-9H-carbazole-1-carboxamide

생성물 1

HCID 666047513-(3-chloro-4-(morpholinomethyl)phenyl)-7-(pyridin-3-yl)-9H-carbazole-1-carboxamide

시약·촉매·용매 1

HCID 178418807HCID 178418807, 화합물촉매

반응 조건

온도
105 °C

실험 절차

To the reaction mixture above (481B) was added 4-(2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)morpholine 477B (0.098 g, 0.289 mmol) and additional PdCl2(dppf)-CH2Cl2 adduct (0.020 g, 0.024 mmol). The mixture was heated in microwave at 105° C. for 1 hr. The mixture was filtered and then purified using preparative HPLC to give titled product. MS (ESI) m/z 495.19 (M−H)−.

후처리

  1. filtrationThe mixture was filtered
  2. custompurified

출처 및 근거

ORD 기록
ord-9152a8ec86a04c5aadf63fb8743ff8df
출처 데이터셋
uspto-grants-2014_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08815840B2

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