3-Chloropropanesulphonyl chloride → 4-(1,1-Dioxo-1,2-thiazolidin-2-yl)-2-methylbenzoic acid

HRID 2411154노트

반응식

HRID 2411154 반응식
[NH2:1][C:2]1[CH:12]=[CH:11][C:5]([C:6]([O:8]CC)=[O:7])=[C:4]([CH3:13])[CH:3]=1.Cl[CH2:15][CH2:16][CH2:17][S:18](Cl)(=[O:20])=[O:19]>>[O:19]=[S:18]1(=[O:20])[CH2:17][CH2:16][CH2:15][N:1]1[C:2]1[CH:12]=[CH:11][C:5]([C:6]([OH:8])=[O:7])=[C:4]([CH3:13])[CH:3]=1

참가 물질

3

반응물 2

HCID 154103-Chloropropanesulphonyl chlorideHCID 24721080Ethyl 4-amino-2-methylbenzoate

생성물 1

HCID 545952974-(1,1-Dioxo-1,2-thiazolidin-2-yl)-2-methylbenzoic acid

실험 절차

Using ethyl 4-amino-2-methylbenzoate (5.3 g) and 3-chloropropane-1-sulfonyl chloride (4.8 mL) and by the reaction and treatment in the same manner as in Preparation Example 16, the title compound (6.49 g) was obtained.

후처리

  1. customby the reaction and treatment in the same manner
  2. customas in Preparation Example 16

출처 및 근거

ORD 기록
ord-913c5662c45846468d131d57d392b679
출처 데이터셋
uspto-grants-2014_08
특허 번호
US08816079B2

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