3-Chloropropanesulphonyl chloride → Methyl 4-[1-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)-1-methylethyl]benzoate

반응식

[NH2:1][C:2]([C:5]1[CH:14]=[CH:13][C:8]([C:9]([O:11][CH3:12])=[O:10])=[CH:7][CH:6]=1)([CH3:4])[CH3:3].Cl[CH2:16][CH2:17][CH2:18][S:19](Cl)(=[O:21])=[O:20]>>[O:20]=[S:19]1(=[O:21])[CH2:18][CH2:17][CH2:16][N:1]1[C:2]([C:5]1[CH:14]=[CH:13][C:8]([C:9]([O:11][CH3:12])=[O:10])=[CH:7][CH:6]=1)([CH3:3])[CH3:4]

참가 물질

반응물 2

HCID 154103-Chloropropanesulphonyl chloride

HCID 57572309Methyl 4-(2-aminopropan-2-yl)benzoate

생성물 1

HCID 71252862Methyl 4-[1-(1,1-dioxo-1lambda6-isothiazolidin-2-yl)-1-methylethyl]benzoate

실험 절차

Using methyl 4-(1-amino-1-methylethyl)benzoate (570 mg) and 3-chloropropane-1-sulfonyl chloride (0.47 mL) and by the reaction and treatment in the same manner as in Preparation Example 17, the title compound (862 mg) was obtained.

후처리

customby the reaction and treatment in the same manner
customas in Preparation Example 17

출처 및 근거

ORD 기록: ord-56068c774a014b379e91b2179bd9beef
출처 데이터셋: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08816079B2

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