Methanesulfonyl chloride → methyl (S)-4-(1-methanesulfonylaminoethyl)benzoate

반응식

[NH2:1][C@H:2]([C:4]1[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][CH:5]=1)[CH3:3].[CH3:14][S:15](Cl)(=[O:17])=[O:16]>>[CH3:14][S:15]([NH:1][C@H:2]([C:4]1[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][CH:5]=1)[CH3:3])(=[O:17])=[O:16]

참가 물질

반응물 2

HCID 31297Methanesulfonyl chloride

HCID 17751895Methyl 4-((1S)-1-aminoethyl)benzoate

생성물 1

HCID 71262918methyl (S)-4-(1-methanesulfonylaminoethyl)benzoate

실험 절차

Using methyl (S)-4-(1-aminoethyl)benzoate (0.61 g) and methanesulfonyl chloride (0.29 mL) and by the reaction and treatment in the same manner as in Preparation Example 71, the title compound (0.81 g) was obtained.

후처리

customby the reaction and treatment in the same manner
customas in Preparation Example 71

출처 및 근거

ORD 기록: ord-fb924fb53f7e423d92e701fbc088fc69
출처 데이터셋: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08816079B2

반응 노트

불러오는 중…