N,N-bis(2-chloroethyl)-p-toluenesulphonamide → 1-(4-Methyl-2-trifluoromethylphenyl)piperazine

HRID 2411228노트

반응식

HRID 2411228 반응식
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([NH2:8])=[C:4]([C:9]([F:12])([F:11])[F:10])[CH:3]=1.Cl[CH2:14][CH2:15][N:16]([CH2:27][CH2:28]Cl)S(C1C=CC(C)=CC=1)(=O)=O>>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:28][CH2:27][NH:16][CH2:15][CH2:14]2)=[C:4]([C:9]([F:10])([F:11])[F:12])[CH:3]=1

참가 물질

3

반응물 2

HCID 96039N,N-bis(2-chloroethyl)-p-toluenesulphonamideHCID 27377104-Methyl-2-(trifluoromethyl)aniline

생성물 1

HCID 213638351-(4-Methyl-2-trifluoromethylphenyl)piperazine수율 26.4%

실험 절차

Using 4-methyl-2-trifluoromethylphenylamine (1 g) and N,N-bis(2-chloroethyl)-p-toluenesulfonamide (1.69 g) and by the reaction and treatment in the same manner as in Preparation Example 95, the title compound (368 mg) was obtained.

후처리

  1. customby the reaction and treatment in the same manner
  2. customas in Preparation Example 95

출처 및 근거

ORD 기록
ord-7ae19ebd6fbd4d77aceb3d0a2b2ca217
출처 데이터셋
uspto-grants-2014_08
특허 번호
US08816079B2

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