1-(2,4-Xylyl)piperazine → HCID 58484755, 화합물

HRID 2411246노트

반응식

HRID 2411246 반응식
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[CH:4][N:3]=1.[CH3:11][C:12]1[CH:17]=[C:16]([CH3:18])[CH:15]=[CH:14][C:13]=1[N:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1>>[Br:1][C:2]1[N:3]=[CH:4][C:5]([C:6]([N:22]2[CH2:23][CH2:24][N:19]([C:13]3[CH:14]=[CH:15][C:16]([CH3:18])=[CH:17][C:12]=3[CH3:11])[CH2:20][CH2:21]2)=[O:8])=[CH:9][CH:10]=1

참가 물질

3

반응물 2

HCID 705441-(2,4-Xylyl)piperazineHCID 2389326-Bromonicotinic acid

생성물 1

HCID 58484755HCID 58484755, 화합물수율 102.5%

실험 절차

Using 6-bromonicotinic acid (2 g) and 1-(2,4-dimethylphenyl)piperazine (1.9 g) and by the reaction and treatment in the same manner as in Preparation Example 109, the title compound (3.8 g) was obtained.

후처리

  1. customby the reaction and treatment in the same manner
  2. customas in Preparation Example 109

출처 및 근거

ORD 기록
ord-a07c5c7d88dc4289ab3c8926c78d6f43
출처 데이터셋
uspto-grants-2014_08
특허 번호
US08816079B2

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