4-Bromo-2-methanesulfonylbenzoic acid → (4-Bromo-2-methanesulfonylphenyl)[4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanone
반응식
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[C:4]([S:11]([CH3:14])(=[O:13])=[O:12])[CH:3]=1.Cl.[CH3:16][C:17]1[C:18]([N:25]2[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]2)=[N:19][C:20]([CH3:24])=[C:21]([CH3:23])[CH:22]=1>>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:28]2[CH2:29][CH2:30][N:25]([C:18]3[C:17]([CH3:16])=[CH:22][C:21]([CH3:23])=[C:20]([CH3:24])[N:19]=3)[CH2:26][CH2:27]2)=[O:8])=[C:4]([S:11]([CH3:14])(=[O:13])=[O:12])[CH:3]=1참가 물질
3
실험 절차
Using 4-bromo-2-methanesulfonylbenzoic acid (3.5 g) and 1-(3,5,6-trimethylpyridin-2-yl)piperazine hydrochloride (3 g) described in Preparation Example 91 and by the reaction and treatment in the same manner as in Preparation Example 119, the title compound (3 g) was obtained.
후처리
- customdescribed in Preparation Example 91 and by the reaction and treatment in the same manner as in Preparation Example 119