4-Bromo-2-fluorobenzoyl chloride → (4-Bromo-2-fluorophenyl) [4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanone

HRID 2411259노트

반응식

HRID 2411259 반응식
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[C:4]([F:11])[CH:3]=1.Cl.[CH3:13][C:14]1[C:15]([N:22]2[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]2)=[N:16][C:17]([CH3:21])=[C:18]([CH3:20])[CH:19]=1>>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:25]2[CH2:26][CH2:27][N:22]([C:15]3[C:14]([CH3:13])=[CH:19][C:18]([CH3:20])=[C:17]([CH3:21])[N:16]=3)[CH2:23][CH2:24]2)=[O:7])=[C:4]([F:11])[CH:3]=1

참가 물질

3

반응물 2

HCID 27340264-Bromo-2-fluorobenzoyl chlorideHCID 673810521-(3,5,6-Trimethylpyridin-2-yl)piperazine hydrochloride

생성물 1

HCID 58484847(4-Bromo-2-fluorophenyl) [4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanone수율 59.5%

실험 절차

Using 4-bromo-2-fluorobenzoyl chloride (5 g) and 1-(3,5,6-trimethylpyridin-2-yl)piperazine hydrochloride (5 g) described in Preparation Example 91 and by the reaction and treatment in the same manner as in Preparation Example 108, the title compound (5 g) was obtained.

후처리

  1. customdescribed in Preparation Example 91 and by the reaction and treatment in the same manner as in Preparation Example 108

출처 및 근거

ORD 기록
ord-ad0e3972d124424fad6ecec92825a17c
출처 데이터셋
uspto-grants-2014_08
특허 번호
US08816079B2

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