1-(2,4-Xylyl)piperazine → HCID 71252418, 화합물

HRID 2411267노트

반응식

HRID 2411267 반응식
[NH2:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[C:4]([CH3:11])[N:3]=1.[CH3:12][C:13]1[CH:18]=[C:17]([CH3:19])[CH:16]=[CH:15][C:14]=1[N:20]1[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]1>>[NH2:1][C:2]1[N:3]=[C:4]([CH3:11])[C:5]([C:6]([N:23]2[CH2:24][CH2:25][N:20]([C:14]3[CH:15]=[CH:16][C:17]([CH3:19])=[CH:18][C:13]=3[CH3:12])[CH2:21][CH2:22]2)=[O:8])=[CH:9][CH:10]=1

참가 물질

3

반응물 2

HCID 705441-(2,4-Xylyl)piperazineHCID 288755296-Amino-2-methylpyridine-3-carboxylic acid

생성물 1

HCID 71252418HCID 71252418, 화합물수율 16.9%

실험 절차

Using 6-amino-2-methylnicotinic acid (500 mg) and 1-(2,4-dimethylphenyl)piperazine (657 mg) and by the reaction and treatment in the same manner as in Preparation Example 109, the title compound (180 mg) was obtained.

후처리

  1. customby the reaction and treatment in the same manner
  2. customas in Preparation Example 109

출처 및 근거

ORD 기록
ord-9fa3c233a3ee4e2384eced989b377e18
출처 데이터셋
uspto-grants-2014_08
특허 번호
US08816079B2

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