1-(5-Bromo-3-methylpyridin-2-yl)piperazine → HCID 58484740, 화합물

반응식

[F:1][C:2]1[CH:10]=[C:9]([CH3:11])[C:5]([C:6]([OH:8])=O)=[CH:4][N:3]=1.[Br:12][C:13]1[CH:14]=[C:15]([CH3:25])[C:16]([N:19]2[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]2)=[N:17][CH:18]=1>>[Br:12][C:13]1[CH:14]=[C:15]([CH3:25])[C:16]([N:19]2[CH2:20][CH2:21][N:22]([C:6]([C:5]3[CH:4]=[N:3][C:2]([F:1])=[CH:10][C:9]=3[CH3:11])=[O:8])[CH2:23][CH2:24]2)=[N:17][CH:18]=1

참가 물질

반응물 2

HCID 467392701-(5-Bromo-3-methylpyridin-2-yl)piperazine

HCID 467392746-Fluoro-4-methylpyridine-3-carboxylic acid

생성물 1

HCID 58484740HCID 58484740, 화합물수율 86.8%

실험 절차

Using 6-fluoro-4-methylnicotinic acid (1.00 g) and 1-(5-bromo-3-methylpyridin-2-yl)piperazine (1.65 g) and by the reaction and treatment in the same manner as in Preparation Example 111, the title compound (2.20 g) was obtained.

후처리

customby the reaction and treatment in the same manner
customas in Preparation Example 111

출처 및 근거

ORD 기록: ord-fab4b36cb0cd42b9b664d2b8db0c9d9a
출처 데이터셋: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08816079B2

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