1-(2,4-Xylyl)piperazine → (4-Amino-2-trifluoromethylphenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone

HRID 2411281노트

반응식

HRID 2411281 반응식
[N+:1]([C:4]1[CH:12]=[CH:11][C:7]([C:8]([OH:10])=O)=[C:6]([C:13]([F:16])([F:15])[F:14])[CH:5]=1)([O-])=O.[CH3:17][C:18]1[CH:23]=[C:22]([CH3:24])[CH:21]=[CH:20][C:19]=1[N:25]1[CH2:30][CH2:29][NH:28][CH2:27][CH2:26]1>>[NH2:1][C:4]1[CH:12]=[CH:11][C:7]([C:8]([N:28]2[CH2:29][CH2:30][N:25]([C:19]3[CH:20]=[CH:21][C:22]([CH3:24])=[CH:23][C:18]=3[CH3:17])[CH2:26][CH2:27]2)=[O:10])=[C:6]([C:13]([F:16])([F:15])[F:14])[CH:5]=1

참가 물질

3

반응물 2

HCID 705441-(2,4-Xylyl)piperazineHCID 27827374-Nitro-2-(trifluoromethyl)benzoic acid

생성물 1

HCID 86676758(4-Amino-2-trifluoromethylphenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone수율 106.3%

실험 절차

Using 4-nitro-2-trifluoromethylbenzoic acid (500 mg) and 1-(2,4-dimethylphenyl)piperazine (403 mg) and by the reaction and treatment in the same manner as in Preparation Example 148, the title compound (850 mg) was obtained.

후처리

  1. customby the reaction and treatment in the same manner
  2. customas in Preparation Example 148

출처 및 근거

ORD 기록
ord-a0489e466a9349c3a9e8ff44c57850b1
출처 데이터셋
uspto-grants-2014_08
특허 번호
US08816079B2

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