Sodium Iodide → [4-(2,4-Dimethylphenyl)piperazin-1-yl](6-iodopyridin-3-yl)methanone

HRID 2411298노트

반응식

HRID 2411298 반응식
Br[C:2]1[N:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][C:17]=3[CH3:23])[CH2:12][CH2:11]2)=[O:9])=[CH:4][CH:3]=1.[I-:24].[Na+]>[Cu]I>[CH3:23][C:17]1[CH:18]=[C:19]([CH3:22])[CH:20]=[CH:21][C:16]=1[N:13]1[CH2:14][CH2:15][N:10]([C:8]([C:5]2[CH:6]=[N:7][C:2]([I:24])=[CH:3][CH:4]=2)=[O:9])[CH2:11][CH2:12]1

참가 물질

4

반응물 2

HCID 5238Sodium IodideHCID 58484755HCID 58484755, 화합물

생성물 1

HCID 86676763[4-(2,4-Dimethylphenyl)piperazin-1-yl](6-iodopyridin-3-yl)methanone수율 62.1%

시약·촉매·용매 1

HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)촉매

실험 절차

Using (6-bromopyridin-3-yl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone (487 mg) described in Preparation Example 115, sodium iodide (389 mg) and copper(I) iodide (123 mg) and by the reaction and treatment in the same manner as in Preparation Example 154, the title compound (340.6 mg) was obtained.

출처 및 근거

ORD 기록
ord-e7f19f13b8dd46d7b4335aae1fe0ab00
출처 데이터셋
uspto-grants-2014_08
특허 번호
US08816079B2

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