4-Bromobenzoyl chloride → (4-Bromophenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone

HRID 2411306노트

반응식

HRID 2411306 반응식
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][CH:3]=1.[CH3:11][C:12]1[CH:17]=[C:16]([CH3:18])[CH:15]=[CH:14][C:13]=1[N:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1>>[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:22]2[CH2:23][CH2:24][N:19]([C:13]3[CH:14]=[CH:15][C:16]([CH3:18])=[CH:17][C:12]=3[CH3:11])[CH2:20][CH2:21]2)=[O:7])=[CH:4][CH:3]=1

참가 물질

3

반응물 2

HCID 685154-Bromobenzoyl chlorideHCID 705441-(2,4-Xylyl)piperazine

생성물 1

HCID 58484623(4-Bromophenyl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone수율 72.9%

실험 절차

Using 4-bromobenzoyl chloride (25 g) and 1-(2,4-dimethylphenyl)piperazine (22 g) and by the reaction and treatment in the same manner as in Preparation Example 108, the title compound (31 g) was obtained.

후처리

  1. customby the reaction and treatment in the same manner
  2. customas in Preparation Example 108

출처 및 근거

ORD 기록
ord-c83b198c976a425595a535bf355a1454
출처 데이터셋
uspto-grants-2014_08
특허 번호
US08816079B2

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