6-Fluoro-4-methylpyridine-3-carboxylic acid → HCID 58484588, 화합물

HRID 2411315노트

반응식

HRID 2411315 반응식
[F:1][C:2]1[CH:10]=[C:9]([CH3:11])[C:5]([C:6]([OH:8])=O)=[CH:4][N:3]=1.[CH:12]1([C:15]2[CH:20]=[C:19]([CH:21]3[CH2:23][CH2:22]3)[CH:18]=[CH:17][C:16]=2[N:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)[CH2:14][CH2:13]1>>[CH:12]1([C:15]2[CH:20]=[C:19]([CH:21]3[CH2:23][CH2:22]3)[CH:18]=[CH:17][C:16]=2[N:24]2[CH2:25][CH2:26][N:27]([C:6]([C:5]3[CH:4]=[N:3][C:2]([F:1])=[CH:10][C:9]=3[CH3:11])=[O:8])[CH2:28][CH2:29]2)[CH2:13][CH2:14]1

참가 물질

3

반응물 2

HCID 467392746-Fluoro-4-methylpyridine-3-carboxylic acidHCID 67381204HCID 67381204, 화합물

생성물 1

HCID 58484588HCID 58484588, 화합물수율 103.8%

실험 절차

Using 6-fluoro-4-methylnicotinic acid (386 mg) and 1-(2,4-dicyclopropylphenyl)piperazine (650 mg) described in Preparation Example 101 and by the reaction and treatment in the same manner as in Preparation Example 118, the title compound (980 mg) was obtained.

후처리

  1. customdescribed in Preparation Example 101 and by the reaction and treatment in the same manner as in Preparation Example 118

출처 및 근거

ORD 기록
ord-2857f953ab9e4c88a45d7b07ef7bb419
출처 데이터셋
uspto-grants-2014_08
특허 번호
US08816079B2

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