6-Bromonicotinic acid → 2-[4-(6-Bromopyridine-3-carbonyl)piperazin-1-yl]-5-methylnicotinonitrile

HRID 2411320노트

반응식

HRID 2411320 반응식
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[CH:4][N:3]=1.[C:11]([C:13]1[C:14]([N:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)=[N:15][CH:16]=[C:17]([CH3:19])[CH:18]=1)#[N:12]>>[Br:1][C:2]1[N:3]=[CH:4][C:5]([C:6]([N:23]2[CH2:24][CH2:25][N:20]([C:14]3[N:15]=[CH:16][C:17]([CH3:19])=[CH:18][C:13]=3[C:11]#[N:12])[CH2:21][CH2:22]2)=[O:8])=[CH:9][CH:10]=1

참가 물질

3

반응물 2

HCID 2389326-Bromonicotinic acidHCID 712522894-(3-Cyano-5-methylpyridin-2-yl)piperazine

생성물 1

HCID 866767642-[4-(6-Bromopyridine-3-carbonyl)piperazin-1-yl]-5-methylnicotinonitrile수율 79.2%

실험 절차

Using 6-bromonicotinic acid (303 mg) and 4-(3-cyano-5-methylpyridin-2-yl)piperazine (303 mg) described in Preparation Example 107 and by the reaction and treatment in the same manner as in Preparation Example 111, the title compound (458 mg) was obtained.

후처리

  1. customdescribed in Preparation Example 107 and by the reaction and treatment in the same manner as in Preparation Example 111

출처 및 근거

ORD 기록
ord-7eac7b0eb0344ceead57a10fd8a1d035
출처 데이터셋
uspto-grants-2014_08
특허 번호
US08816079B2

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