6-Bromonicotinic acid → (6-Bromopyridin-3-yl)[4-(p-tolyloxy)piperidin-1-yl]methanone

HRID 2411330

반응식

HRID 2411330 반응식
[C:1]1([CH3:14])[CH:6]=[CH:5][C:4]([O:7][CH:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[CH:3][CH:2]=1.[Br:15][C:16]1[CH:24]=[CH:23][C:19]([C:20](O)=[O:21])=[CH:18][N:17]=1>>[Br:15][C:16]1[N:17]=[CH:18][C:19]([C:20]([N:11]2[CH2:12][CH2:13][CH:8]([O:7][C:4]3[CH:3]=[CH:2][C:1]([CH3:14])=[CH:6][CH:5]=3)[CH2:9][CH2:10]2)=[O:21])=[CH:23][CH:24]=1

참가 물질

3

반응물 2

HCID 2389326-Bromonicotinic acidHCID 38374974-(4-Methylphenoxy)piperidine

생성물 1

HCID 58484591(6-Bromopyridin-3-yl)[4-(p-tolyloxy)piperidin-1-yl]methanone수율 99.9%

실험 절차

Using 4-(p-tolyloxy)piperidine (765 mg) and 6-bromonicotinic acid (808 mg) and by the reaction and treatment in the same manner as in Preparation Example 118, the title compound (1.5 g) was obtained.

후처리

  1. customby the reaction and treatment in the same manner
  2. customas in Preparation Example 118

출처 및 근거

ORD 기록
ord-e46681dc325d47bfaf2d19e9ad6d59c7
출처 데이터셋
uspto-grants-2014_08
특허 번호
US08816079B2

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