6-Bromonicotinic acid → (6-Bromopyridin-3-yl)[4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanone

HRID 2411339노트

반응식

HRID 2411339 반응식
[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[CH:4][N:3]=1.[CH3:11][C:12]1[C:13]([N:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)=[N:14][C:15]([CH3:19])=[C:16]([CH3:18])[CH:17]=1>>[Br:1][C:2]1[N:3]=[CH:4][C:5]([C:6]([N:23]2[CH2:24][CH2:25][N:20]([C:13]3[C:12]([CH3:11])=[CH:17][C:16]([CH3:18])=[C:15]([CH3:19])[N:14]=3)[CH2:21][CH2:22]2)=[O:8])=[CH:9][CH:10]=1

참가 물질

3

반응물 2

HCID 2389326-Bromonicotinic acidHCID 584848231-(3,5,6-Trimethylpyridin-2-yl)piperazine

생성물 1

HCID 58484612(6-Bromopyridin-3-yl)[4-(3,5,6-trimethylpyridin-2-yl)piperazin-1-yl]methanone수율 88.2%

실험 절차

Using 6-bromonicotinic acid (606 mg) and 1-(3,5,6-trimethylpyridin-2-yl)piperazine (616 mg) described in Preparation Example 92 and by the reaction and treatment in the same manner as in Preparation Example 111, the title compound (1.03 g) was obtained.

후처리

  1. customdescribed in Preparation Example 92 and by the reaction and treatment in the same manner as in Preparation Example 111

출처 및 근거

ORD 기록
ord-2ccb286a626c4aabbb35484de828acdc
출처 데이터셋
uspto-grants-2014_08
특허 번호
US08816079B2

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