1-(3,5-Dimethylpyridin-2-yl)piperazine → HCID 86676765, 화합물

HRID 2411355노트

반응식

HRID 2411355 반응식
[Br:1][C:2]1[CH:10]=[C:9]([CH3:11])[C:5]([C:6]([OH:8])=O)=[CH:4][N:3]=1.[CH3:12][C:13]1[C:14]([N:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)=[N:15][CH:16]=[C:17]([CH3:19])[CH:18]=1>>[Br:1][C:2]1[N:3]=[CH:4][C:5]([C:6]([N:23]2[CH2:24][CH2:25][N:20]([C:14]3[C:13]([CH3:12])=[CH:18][C:17]([CH3:19])=[CH:16][N:15]=3)[CH2:21][CH2:22]2)=[O:8])=[C:9]([CH3:11])[CH:10]=1

참가 물질

3

반응물 2

HCID 584844961-(3,5-Dimethylpyridin-2-yl)piperazineHCID 722121586-Bromo-4-methyl-3-pyridinecarboxylic acid

생성물 1

HCID 86676765HCID 86676765, 화합물수율 97.7%

실험 절차

Using 6-bromo-4-methylnicotinic acid (500 mg) and 1-(3,5-dimethylpyridin-2-yl)piperazine (443 mg) described in Preparation Example 79 and by the reaction and treatment in the same manner as in Preparation Example 111, the title compound (880 mg) was obtained.

후처리

  1. customdescribed in Preparation Example 79 and by the reaction and treatment in the same manner as in Preparation Example 111

출처 및 근거

ORD 기록
ord-e09ec244a812476aa832513335e741b7
출처 데이터셋
uspto-grants-2014_08
특허 번호
US08816079B2

반응 노트

불러오는 중…