5-Bromopyrazine-2-carboxylic acid → HCID 86676767, 화합물

HRID 2411359노트

반응식

HRID 2411359 반응식
[Br:1][C:2]1[N:3]=[CH:4][C:5]([C:8]([OH:10])=O)=[N:6][CH:7]=1.[CH3:11][C:12]1[C:13]([N:19]2[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]2)=[N:14][CH:15]=[C:16]([CH3:18])[CH:17]=1>>[Br:1][C:2]1[N:3]=[CH:4][C:5]([C:8]([N:22]2[CH2:23][CH2:24][N:19]([C:13]3[C:12]([CH3:11])=[CH:17][C:16]([CH3:18])=[CH:15][N:14]=3)[CH2:20][CH2:21]2)=[O:10])=[N:6][CH:7]=1

참가 물질

3

반응물 2

HCID 187797905-Bromopyrazine-2-carboxylic acidHCID 584844961-(3,5-Dimethylpyridin-2-yl)piperazine

생성물 1

HCID 86676767HCID 86676767, 화합물수율 69.5%

실험 절차

Using 5-bromopyrazine-2-carboxylic acid (203 mg) and 1-(3,5-dimethylpyridin-2-yl)piperazine (191 mg) described in Preparation Example 79 and by the reaction and treatment in the same manner as in Preparation Example 118, the title compound (261 mg) was obtained.

후처리

  1. customdescribed in Preparation Example 79 and by the reaction and treatment in the same manner as in Preparation Example 118

출처 및 근거

ORD 기록
ord-ebbee38ada434d988d5ef2b3a423fe0b
출처 데이터셋
uspto-grants-2014_08
특허 번호
US08816079B2

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