5-Bromopyrazine-2-carboxylic acid → HCID 86676769, 화합물

HRID 2411370노트

반응식

HRID 2411370 반응식
[Br:1][C:2]1[N:3]=[CH:4][C:5]([C:8]([OH:10])=O)=[N:6][CH:7]=1.[CH:11]1([C:14]2[CH:15]=[C:16]([CH3:26])[C:17]([N:20]3[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]3)=[N:18][CH:19]=2)[CH2:13][CH2:12]1>>[Br:1][C:2]1[N:3]=[CH:4][C:5]([C:8]([N:23]2[CH2:24][CH2:25][N:20]([C:17]3[C:16]([CH3:26])=[CH:15][C:14]([CH:11]4[CH2:12][CH2:13]4)=[CH:19][N:18]=3)[CH2:21][CH2:22]2)=[O:10])=[N:6][CH:7]=1

참가 물질

3

반응물 2

HCID 187797905-Bromopyrazine-2-carboxylic acidHCID 584847181-(5-Cyclopropyl-3-methylpyridin-2-yl)piperazine

생성물 1

HCID 86676769HCID 86676769, 화합물수율 65.6%

실험 절차

Using 5-bromopyrazine-2-carboxylic acid (1 g) and 1-(5-cyclopropyl-3-methylpyridin-2-yl)piperazine (1.07 g) described in Preparation Example 83 and by the reaction and treatment in the same manner as in Preparation Example 118, the title compound (1.3 g) was obtained.

후처리

  1. customdescribed in Preparation Example 83 and by the reaction and treatment in the same manner as in Preparation Example 118

출처 및 근거

ORD 기록
ord-b7b2fca0d1164dc8ab30fd4099a47bfa
출처 데이터셋
uspto-grants-2014_08
특허 번호
US08816079B2

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