1-(3,5-Dimethylpyridin-2-yl)piperazine → HCID 71577776, 화합물

반응식

[Br:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[C:4]([CH3:11])[N:3]=1.[CH3:12][C:13]1[C:14]([N:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)=[N:15][CH:16]=[C:17]([CH3:19])[CH:18]=1>>[Br:1][C:2]1[N:3]=[C:4]([CH3:11])[C:5]([C:6]([N:23]2[CH2:24][CH2:25][N:20]([C:14]3[C:13]([CH3:12])=[CH:18][C:17]([CH3:19])=[CH:16][N:15]=3)[CH2:21][CH2:22]2)=[O:8])=[CH:9][CH:10]=1

참가 물질

반응물 2

HCID 584844961-(3,5-Dimethylpyridin-2-yl)piperazine

HCID 716915676-BroMo-2-Methyl-nicotinic acid

생성물 1

HCID 71577776HCID 71577776, 화합물수율 50.8%

실험 절차

Using 6-bromo-2-methylnicotinic acid (986 mg) and 1-(3,5-dimethylpyridin-2-yl)piperazine (917 mg) described in Preparation Example 79 and by the reaction and treatment in the same manner as in Preparation Example 111, the title compound (903 mg) was obtained.

후처리

customdescribed in Preparation Example 79 and by the reaction and treatment in the same manner as in Preparation Example 111

출처 및 근거

ORD 기록: ord-2fb2964f36c644fa88b6bdf0679733cd
출처 데이터셋: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08816079B2

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