3,5-Dimethyl-2,4-Imidazolidinedione → Methyl 6-(3,5-dimethyl-2,4-dioxoimidazolidin-1-yl)-2-methylnicotinate

반응식

Br[C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:4]([CH3:12])[N:3]=1.[CH3:13][N:14]1[C:18](=[O:19])[CH:17]([CH3:20])[NH:16][C:15]1=[O:21]>>[CH3:13][N:14]1[C:18](=[O:19])[CH:17]([CH3:20])[N:16]([C:2]2[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[C:4]([CH3:12])[N:3]=2)[C:15]1=[O:21]

참가 물질

반응물 2

HCID 101540613,5-Dimethyl-2,4-Imidazolidinedione

HCID 71691566Methyl 6-bromo-2-methylpyridine-3-carboxylate

생성물 1

HCID 71252642Methyl 6-(3,5-dimethyl-2,4-dioxoimidazolidin-1-yl)-2-methylnicotinate수율 16.4%

실험 절차

Using methyl 6-bromo-2-methylnicotinate (96 mg) and 3,5-dimethylimidazolidine-2,4-dione (107 mg) described in Preparation Example 217 and by the reaction and treatment in the same manner as in Preparation Example 48, the title compound (19 mg) was obtained.

후처리

customdescribed in Preparation Example 217 and by the reaction and treatment in the same manner as in Preparation Example 48

출처 및 근거

ORD 기록: ord-c55045bd276a4ea2bea0320410589f0a
출처 데이터셋: uspto-grants-2014_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08816079B2

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